Dr Akeel Alisa

Job title

Consultant gastroenterologist and general physician

Qualifications

BSc, MB;BChir (Cambr), MRCP (Lond), MRCP (Gastro), MD (UCL)

GMC Number

4024590

Contact details

Phone number: 020 8216 4136/4079

Email address: akeel.alisa@nhs.net

Fax: 020 8375 1977

Related services

Gastroenterology, Liver services

Biography

Dr Akeel Alisa qualified from Cambridge University and completed his junior medical training at King’s College Hospital. He then undertook clinical research in hepatology at the Institute of Hepatology (UCL) focusing on the immunological responses in cirrhosis and hepatocellular carcinoma, non-invasive tests for liver fibrosis, gaining experience with liver transplant and the UK first living related liver transplant program. He concluded his higher postgraduate training in gastroenterology and general medicine in London, the South West Thames region. He was then appointed as a consultant gastroenterologist and general physician with an interest in hepatology. He has also an interest in luminal gastroenterology and therapeutic endoscopy and has been appointed as the lead in alcohol services. He is a faculty member at St George’s endoscopy training unit and at the United European Gastroenterology (UEG). He has an interest in teaching at undergraduate and postgraduate levels.

Publications

  • Induction of latency-associated peptide (transforming growth factor-β(1)) expression on CD4+ T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-α production in a transforming growth factor-β-dependent manner. Boswell S, Sharif S, Alisa A, Pereira SP, Williams R, Behboudi S.  Immunology. 2011 Jul;133(3):278-87. 
  • Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy. Anastasiou J, Alisa A, Virtue S, Portmann B, Murray-Lyon I, Williams R. Eur J Gastroenterol Hepatol. 2010 Apr;22(4):474-80. 
  • Expansion of anti-AFP Th1 and Tc1 responses in hepatocellular carcinoma occur in different stages of disease. Behboudi S, Alisa A, Boswell S, Anastassiou J, Pathan AA, Williams R.  Br J Cancer. 2010 Feb 16;102(4):748-53. Epub 2010 Jan 19. 
  • Human CD4(+) T cells recognize an epitope within alpha-fetoprotein sequence and develop into TGF-beta-producing CD4(+) T cells. Alisa A, Boswell S, Pathan AA, Ayaru L, Williams R, Behboudi S. J Immunol. 2008 Apr 1;180(7):5109-17, 
  • Unmasking of alpha-fetoprotein-specific CD4(+) T cell responses in hepatocellular carcinoma patients undergoing embolization. Ayaru L, Pereira SP, Alisa A, Pathan AA, Williams R, Davidson B, Burroughs AK, Meyer T, Behboudi S. J Immunol. 2007 Feb 1;178(3):1914-22 
  • Analysis of CD4+ T-Cell responses to a novel alpha-fetoprotein-derived epitope in hepatocellular carcinoma patients. Alisa A, Ives A, Pathan AA, Navarrete CV, Williams R, Bertoletti A, Behboudi S. Clin Cancer Res. 2005 Sep 15;11(18):6686-94., 
  • Alpha-fetoprotein impairs APC function and induces their apoptosis. Um SH, Mulhall C, Alisa A, Ives AR, Karani J, Williams R, Bertoletti A, Behboudi S. J Immunol. 2004 Aug 1;173(3):1772-8., 
  • Use of fibrin glue (beriplast) in the management of bleeding gastric varices.Datta D, Vlavianos P, Alisa A, Westaby D. Endoscopy. 2003 Aug;35(8):675-8. 
  • Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis. Tilg H, Jalan R, Kaser A, Davies NA, Offner FA, Hodges SJ, Ludwiczek O, Shawcross D, Zoller H, Alisa A, Mookerjee RP, Graziadei I, Datz C, Trauner M, Schuppan D, Obrist P, Vogel W, Williams R. J Hepatol. 2003 Apr;38(4):419-25 
  • Adult-to-adult living donor liver transplant: UK experience. Williams RS, Alisa AA, Karani JB, Muiesan P, Rela SM, Heaton ND. Eur J Gastroenterol Hepatol. 2003 Jan;15(1):7-14., 
  • Extracorporeal liver support with molecular adsorbents recirculating system in patients with severe acute alcoholic hepatitis. Jalan R, Sen S, Steiner C, Kapoor D, Alisa A, Williams R.   J Hepatol. 2003 Jan;38(1):24-31., PMID: 12480556 
  • Living related adult-to-adult liver transplantation: meeting the donor shortage. Williams R, Alisa A, Karani J, Rela M, Heaton N. Antiviral Res. 2001 Nov;52(2):217-23 
  • The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection. Maini MK, Boni C, Lee CK, Larrubia JR, Reignat S, Ogg GS, King AS, Herberg J, Gilson R, Alisa A, Williams R, Vergani D, Naoumov NV, Ferrari C, Bertoletti A.                 J Exp Med. 2000 Apr