Dr Edward J Despott

Job title

Consultant gastroenterologist and GI endoscopist


MD MRCP(UK) MRCP(Gastro) FEBGH MD(Res)(Advanced Endoscopy, Imperial)

GMC Number


Contact details

PA/secretary phone number: 020 7794 0500 ext 38814

PA/secretary email address: nadine.mclaren@nhs.net

Private practice phone number: 020 7794 0500 ext 38814/07599 104 983

Private practice email address: rf.despottprivatepractice@nhs.net

Related services



Dr Edward J Despott is the trust-wide clinical lead of endoscopy services at the Royal Free unit for endoscopy and UCL institute for liver and digestive health (Royal Free campus) in London. He is a consultant gastroenterologist and gastrointestinal (GI) endoscopist whose specialist interests include device assisted enteroscopy (double-balloon enteroscopy (DBE) in particular), capsule endoscopy (CE), therapeutic colonoscopy (particularly complex polypectomy including large endoscopic mucosal resection (EMR)) and transnasal upper GI endoscopy. He is also interested in the diagnosis and management of inflammatory bowel disease and related complications, such as endoscopic management of small bowel and colonic strictures. Since his appointment in 2012, Dr Despott instigated significant advances at the Royal Free unit for endoscopy by making it one of the only two centres in London, and one of a handful in the UK, to offer a comprehensive small bowel endoscopy service including DBE and the development of a tertiary advanced polypectomy service.


  • Dark macules in the upper gastrointestinal tract: An ominous sign. Laskaratos FM, Gillmore R, Clark I, Despott. EJ. Dig Liver Dis. 2014 Aug 14. pii: S1590-8658(14)00444-7.
  • Factors associated with reduced insertion depth at double balloon enteroscopy: A retrospective, multivariate analysis.Murino A, Nakamura M, Despott EJ, Fraser C. Dig Liver Dis. 2014 Jun 26. pii: S1590-8658(14)00399-5. 
  • Fatal enteritis in a renal transplant patient with post-transplant thrombotic microangiopathy undergoing plasma exchange therapy. Owen L, Jones G, Despott EJ, Murray C, Atkinson C, Beal I, Webster DP. J Clin Virol. 2014 Apr;59(4):213-7. 
  • Favorable long-term outcomes of repeat endotherapy for small-intestine vascular lesions by double-balloon endoscopy. Shinozaki S, Yamamoto H, Yano T, Sunada K, Hayashi Y, Shinhata H, Sato H, Despott EJ, Sugano K. Gastrointest Endosc. 2014 Jul;80(1):112-7.
  • Is there a role for emergency small bowel capsule endoscopy in the investigation and management of severe obscure-overt gastrointestinal bleeding? Despott EJ. Ann Gastroenterol. 2013;26(2):178-179. 
  • Endoscopic features of mesenteric panniculitis by double-balloon enteroscopy. Bourikas LA, Despott EJ, Moorghen M, Fraser C. Dig Liver Dis. 2012 Nov;44(11):961. doi: 10.1016/j.dld.2012.06.001. 
  • Small bowel endoscopy in inflammatory bowel disease. Despott EJ, Fraser C. Best Pract Res Clin Gastroenterol. 2012 Jun;26(3):279-91. 
  • A rare case of small bowel intussusception. Murino A, Despott EJ, Hansmann A, Heath P, Fraser C. Endoscopy. 2012;44 Suppl 2 UCTN:E157-8. 
  • Tracheal aspiration of capsule endoscopes: detection, management, and susceptibility. Despott EJ, O'Rourke A, Anikin V, Davison C, Panter S, Bromley J, Plaice J, Corbett M, Fraser C. Dig Dis Sci. 2012 Jul;57(7):1973-4.
  • First report of endoscopic closure of a gastrocolic fistula using an over-the-scope clip system (with video). Murino A, Despott EJ, Vaizey C, Bashir G, Hansmann A, Gupta A, Konieczko K, Fraser C. Gastrointest Endosc. 2012 Apr;75(4):893; discussion 894. 
  • Management of deep looping when failing to progress at double-balloon enteroscopy. Despott EJ, Murino A, Fraser C.Endoscopy. 2011;43 Suppl 2 UCTN:E275-6. 
  • First report of a secondary aortojejunal fistula visualized by small bowel capsule endoscopy. Despott EJ, Murino A, Butcher J, Hussain T, Greenstein D, Naji Y, O'Rourke A, Fraser C. Dig Dis Sci. 2012 Jan;57(1):256-7.
  • An unusual finding at screening colonoscopy: polypoid follicular lymphoma with marginal zone differentiation. Despott EJ, Tadrous PJ, Naresh KN, Savio A, Marshall M, Saunders BP. Endoscopy. 2011;43 Suppl 2 UCTN:E266-7. 
  • Enteral access by double-balloon enteroscopy: an alternative method of direct percutaneous endoscopic jejunostomy placement. Despott EJ, Gabe S, Tripoli E, Konieczko K, Fraser C. Dig Dis Sci. 2011 Feb;56(2):494-8. 
  • First cases of spiral enteroscopy in the UK: let's "torque" about it! Despott EJ, Hughes S, Marden P, Fraser C. Endoscopy. 2010 Jun;42(6):517.
  • Sedation in digestive endoscopy: the Athens international position statements. Cohen LB, Ladas SD, Vargo JJ, Paspatis GA, Bjorkman DJ, Van der Linden P, Axon AT, Axon AE, Bamias G, Despott E, Dinis-Ribeiro M, Fassoulaki A, Hofmann N, Karagiannis JA, Karamanolis D, Maurer W, O'Connor A, Paraskeva K, Schreiber F, Triantafyllou K, Viazis N, Vlachogiannakos J. Aliment Pharmacol Ther. 2010 Aug;32(3):425-42. 
  • Advanced cardiac life support training. Despott EJ, Schreiber F. Digestion. 2010;82(2):113-4. doi: 10.1159/000285587. Epub 2010 Apr 21. 
  • Achieving successful ileal intubation during retrograde double balloon enteroscopy: description of a novel, alternative technique (with video). Despott E, Fraser C. Endoscopy. 2009;41 Suppl 2:E309-10.
  • Effective dilation of small-bowel strictures by double-balloon enteroscopy in patients with symptomatic Crohn's disease (with video). Despott EJ, Gupta A, Burling D, Tripoli E, Konieczko K, Hart A, Fraser C. Gastrointest Endosc. 2009 Nov;70(5):1030-6. doi: 10.1016/j.gie.2009.05.005. Epub 2009 Jul 28.
  • Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED-ECCO consensus. Bourreille A, Ignjatovic A, Aabakken L, Loftus EV Jr, Eliakim R, Pennazio M, Bouhnik Y, Seidman E, Keuchel M, Albert JG, Ardizzone S, Bar-Meir S, Bisschops R, Despott EJ, Fortun PF, Heuschkel R, Kammermeier J, Leighton JA, Mantzaris GJ, Moussata D, Lo S, Paulsen V, Panés J, Radford-Smith G, Reinisch W, Rondonotti E, Sanders DS, Swoger JM, Yamamoto H, Travis S, Colombel JF, Van Gossum A; World Organisation of Digestive Endoscopy (OMED) and the European Crohn's and Colitis Organisation (ECCO). Endoscopy. 2009 Jul;41(7):618-37. 
  • An unusual cause of diarrhea: diffuse intestinal nodular lymphoid hyperplasia in association with selective immunoglobulin A deficiency (with video). Postgate A, Despott E, Talbot I, Phillips R, Aylwin A, Fraser C. Gastrointest Endosc. 2009 Jul;70(1):168-9; discussion 169. 
  • Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy. Postgate A, Despott E, Burling D, Gupta A, Phillips R, O'Beirne J, Patch D, Fraser C. Gastrointest Endosc. 2008 Dec;68(6):1209-14. 
  • Antibiotic therapy: a major cause of drug-induced jaundice in southwest England. Hussaini SH, O'Brien CS, Despott EJ, Dalton HR. Eur J Gastroenterol Hepatol. 2007 Jan;19(1):15-20.