Dr Siobhan Burns

Job title

Reader and consultant in immunology

Qualifications

MB PhD MRCPI(Paeds)

Contact details

Phone number: 020 7794 0500 ext 34519/35161/36662

Email address: siobhan.burns2@nhs.net/siobhan.burns@ucl.ac.uk

Fax: 020 7830 2224

Related services

Immunology

Biography

Dr Burns is a clinical academic with an interest in primary immunodeficiency disorders (PID). Originally trained in paediatric immunology, she has a specialist interest in young adults with immunodeficiency. Her research group focuses on understanding the underlying causes for PID.

Publications

  • Burns SO, Plagnol V, Gutierrez BM, Al Zahrani D, Curtis J, Gaspar M, Hassan A, Jones AM, Malone M, Rampling D, McLatchie A, Doffinger R, Gilmour KC, Henriquez F, Thrasher AJ, Gaspar HB, Nejentsev S.Immunodeficiency and disseminated mycobacterial infection associated with homozygous nonsense mutation of IKKβ⋆. 2014, J Allergy Clin ImmunolMar 26. pii: S0091-6749(14)00185-7. doi: 10.1016/j.jaci.2013.12.1093. [Epub ahead of print] 
  • Ammann S, Elling R, Gyrd-Hansen M, Dückers G, Bredius R, Burns SO, Edgar JD, Worth A, Brandau H, Warnatz K, Zur Stadt U, Hasselblatt P, Schwarz K, Ehl S, Speckmann C. 2014, A new functional assay for the diagnosis of X-linked inhibitor of apoptosis (XIAP) deficiency.Clin Exp Immunol. 2014 Feb 26. doi: 10.1111/cei.12306. [Epub ahead of print]
  • Jones RA, Feng Y, Worth AJ, Thrasher AJ, Burns SO, Martin P 2013, Modelling human wiskott aldrich syndrome protein mutants in zebrafish larvae using live in vivo imaging, J Cell Sci. 2013 Sep 15;126(Pt 18):4077-84. doi: 10.1242/jcs.128728. Epub 2013 Jul 18
  • Worth A.J.J., Metelo J, Bouma G., Moulding D, Fritzsche M, Vernay B, Charras G, Cory G.O.C, Thrasher A.J, Burns S.O. 2013, Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration, Blood; Jan 3;121(1):72-84. doi: 10.1182/blood-2012-01-403857. Epub 2012 Nov 15
  • Burns S.O., Zenner H.L., Plagnol V., Curtis J., Mok K., Eisenhut M., Kumararatne D., Doffinger R., Thrasher A.J., Nejentsev S. 2012, LRBA gene deletion in a patient presenting with autoimmunity without hypogammaglobulinemia, J Allergy Clin Immunol.; Sep 13. pii: S0091-6749(12)01222-5.
  • Plagnol V., Curtis J., Epstein M., Mok K., Stebbings E., Grigoriadou S., Wood N.W., Hambleton S., Burns S.O., Thrasher A., Kumararatne D., Doffinger R., Nejentsev S. 2012, A robust model for read count data in exome sequencing experiments and implications for copy number variant calling, Bioinformatics; Nov 1;28(21):2747-54. doi: 10.1093/bioinformatics/bts526. Epub 2012 Aug 31
  • Recher M., Burns S.O., de la Fuente M.A., Volpi S., Dahlberg C., Walter J.E., Moffitt K., Mathew D., Honke N., Lang P.A., Patrizi L., Falet H., Keszei M., Mizui M., Csizmadia E., Candotti F., Nadeau K., Bouma G., Delmonte O.M., Frugoni F., Fomin A.B., Buchbinder D., Lundequist E.M., Massaad M.J., Tsokos G.C., Hartwig J., Manis J., Terhorst C., Geha R.S., Snapper S., Lang K.S., Malley R., Westerberg L., Thrasher A.J., Notarangelo L.D. 2012, B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice, Blood; Mar 22;119(12):2819-28. 
  • Metelo J., Ward N., Thrasher A.J., Burns S.O. 2011, Lentivectors are efficient tools to manipulate the dendritic cell cytoskeleton, Cytoskeleton; Aug;68(8):434-45, Epub 2011 Jul 29
  • Bouma G., Mendoza-Naranjo A., Blundell M.P., de Falco E., Parsley K.L., Burns S.O., Thrasher A.J. 2011, Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T cell priming, .Blood Sep 1;118(9):2492-501
  • Burns S.O., Killock D.J., Moulding D.A., Metelo J, Nunes J, Taylor R.R., Forge A., Thrasher A.J., Ivetic A. 2010, A congenital activating mutant of WASp causes altered plasma membrane topography and adhesion under flow in lymphocytes, Blood; Jul 1;115(26):5355-65. Epub 2010 Mar 30
  • Albert MH, Bittner TC, Nonoyama S, Notarangelo LD, Burns S, Imai K, Espanol T, Fasth A, Pellier I, Strauss G, Morio T, Gathmann B, Noordzij JG, Fillat C, Hoenig M, Nathrath M, Meindl A, Pagel P, Wintergerst U, Fischer A, Thrasher AJ, Belohradsky BH, Ochs HD 2010, X-linked thrombocytopenia (XLT) due to WAS mutations: Clinical characteristics, long-term outcome, and treatment option, Blood; 2010 Apr 22;115(16):3231-8. Epub 2010 Feb 19
  • Nibali L., O’Dea M., Bouma G., Parkar M., Thrasher A.J, Burns S., Donos N 2009, Genetic variants associated with neutrophil function in aggressive periodontitis and healthy controls, Journal of Periodontology; Apr;81(4):527-34
  • Blundell M.P., Bouma G., Metelo J., Worth A., Calle Y., Cowell L.A., Westerberg L.S., Moulding D.A., Mirando S., Kinnon C., Cory G.O., Jones G. E., Snapper S. B., Burns S.O., Thrasher A. J. 2009, Phosphorylation of WASp is a key regulator of activity and stability in vivo, Proceedings of the National Academy of Sciences; 106(37):15738-43.
  • Bouma G., Doffinger R., Patel  S.Y., Peskett E., Sinclair J., Kumararatne D.S., Davies E.G., Thrasher A.J., Burns S.O. 2009, Impaired neutrophil migration and phagocytosis in IRAK-4 deficiency, British Journal of Haematology; 147(1):153-6
  • Adamovich D.A., Nakamura F., Worth A., Burns S., Thrasher A. J., Hartwig J.H., Snapper S.B. 2009, Activating Mutations of NWASP Alter Shigella Pathogenesis, Biochemical and Biophysical  Research Communications; 384(3):284-9. 
  • Bouma G., Burns S., Thrasher A.J. 2007; Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells, Blood; 110(13):4278-84. 
  • Chou H.C., Antón I. M., Holt M., Curcio C., Lanzardo S., Worth A., Burns S., Thrasher A.J., Jones G.E., Calle Y. 2006, WIP regulates stability and recruitment of WASP to podosomes in migrating dendritic cells, Current Biology;16(23) :2337-44
  • Ancliff P.J., Blundell M.P., Cory G.O., Calle Y., Worth A., Kempski H., Burns S., Jones G.E., Sinclair J., Kinnon C., Hann I.M., Gale R.E., Linch D.C., Thrasher A.J. 2006, Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia, Blood; 108 (7): 2182–9
  • Olivier A., Jeanson-Leh L., Bouma G., Compagno D., Blondeau J., Seye K., Charrier S., Burns S., Thrasher A.J., Danos O., Vainchenker W., Galy A., 2006, A Partial Down-regulation of WASP Is Sufficient to Inhibit Podosome Formation in Dendritic Cells, Molecular Therapy; 13(4):729-37
  • Burns S., Hardy S., Buddle J., Yong K., Jones G.E., Thrasher A. J. 2004, Maturation of DC is associated with changes in motile characteristics and adherence, Cell Motility and Cytoskeleton; 57(2):118-32
  • Burns S., Thrasher A.J., Blundell M., Machesky L., Jones G.E. 2001, Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation, Blood; 98(4):1142-9
  • Dillon M., Brown S., Casey W., Abubaker M.K., Walsh D., Durnin M., Drumm B. 1998, Colonoscopy under General Anaesthesia in Children, Paediatrics; 102 (2pt1): 381-3
  • Cullen A., Brown S., Cafferkey M., O’Brien N., Griffin E., 1998, Incidence of Congenital Infection in the Dublin Maternity Hospitals as detected by the TORCH screen, Journal of Infection; 36(2): 185-8
  • Bouma G., Ancliff P.J., Thrasher A.J. and Burns S.O. 2010, Recent advances in the understanding of neutrophil function, British Journal of Haematology; Nov;151(4):312-26. Epub 2010 Aug 31.
  • Burns S.O., Davies E.G. 2010, Neutrophil dysfunction in children, Paediatrics and Child Health; Volume 20 Issue 11
  • Thrasher A.J., Burns S.O. 2010, WASP: a key immunological multitasker, Nat Rev Immunol.;10(3):182-92
  • Bouma G., Burns S.O., Thrasher A. J. 2009, Wiskott–Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation, Immunobiology; 214(9-10):778-90. 
  • Calle Y., Burns S., Thrasher A.J., Jones G.E. 2006, The leukocyte podosome, European Journal of Cell Biology; 85 (3-4): 151–7
  • Burns S., Thrasher A.J. 2004, Dendritic cells: the bare bones of immunity, Current Biology;14(22):R965-7
  • Burns S., Cory G.O., Vainchenker W., Thrasher A.J. 2004 Mechanisms of WASp-mediated hematologic and immunologic disease, Blood; 104(12):3454-62
  • Thrasher A.J., Burns S., Lorenzi R., Jones G.E. 2000, The Wiskott-Aldrich Syndrome: disordered actin dynamics in haematopoietic cells Immunological Reviews;178:118-28
  • Thrasher A.J. and Burns S. 1999, Wiskott-Aldrich Syndrome: A disorder of haematopoietic cytoskeleton regulation, Microscopy and Research Techniques; 47 1-7
  • Burns S., Bouma G., Thrasher A.J. 2006, Wiskott-Aldrich syndrome as model of cytoskeleton defect, In: Lymphocyte trafficking in health and disease. pp211-231. Eds Badolato R and Sozzani S.  Birkhäuser Verlag AG, Basel