Mr Peng H Tan

Job title

Consultant oncoplastic breast surgeon

Qualifications

MBBS (Lond), MSc (Lond), MRCS, PhD (Lond), MD (Lond), FRCS (Gen Surg)

GMC Number

4258223

Contact details

PA/secretary phone number: 020 7830 2758/020 7830 2966

PA/secretary email address: christine.williams13@nhs.net / satya.barham@nhs.net

Fax: 020 7830 2194/020 7317 7608

Private practice email address: peng.tan@nhs.net

Related services

Breast surgery, Plastic surgery

Biography

Mr Tan is a consultant oncoplastic breast surgeon. He graduated with MBBS and MSc degree, from Imperial College London in 1995 and was in the basic surgical training programmes in Cambridge and London leading to a MRCS diploma. He was then awarded with the MRC (UK) fellowship researching into genetic manipulation of immune and vascular cells of which culminated in PhD and MD degrees with University of London.

Mr Tan then went to Oxford University to become its lecturer in surgery and completed his higher surgical training programmes with the Oxford School of Surgery. In Oxford, he was awarded with Sir Peter Morris Surgeon Scientist in order to start up his research programme on the development of a vaccine for breast cancer. From Oxford, he went onto further sub-speciality training in oncoplastic surgery at the Royal Marsden Foundation Trust and the Imperial College Healthcare NHS Trust. He then completed his general surgery and oncoplastic breast training, leading to his fellowship with the Royal College of Surgeons.

Publications

  • Evolving role of adiponectin in cancer – controversies and update (Review Article). A Katira, PH Tan (Senior Authorship). Cancer Biology and Medicine 2016 Mar;13(1):101-19. doi: 10.28092/j.issn.2095-3941.2015.0092.
  • Adiponectin and its receptor signaling: an anti-cancer therapeutic target and its implications for anti-tumor immunity (Review Article) (Impact Factor 5.139 @ 2014 Thomson Reuters, Journal Citation Reports). A Katira, PH Tan (Senior Authorship). Expert Opinion Therapeutic Targets May 2015 19(8):1105-25  
  • Adiponectin Receptor Signaling on Dendritic Cells Blunts Antitumor Immunity (Original Research Article) (Impact Factor 9.329 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, HE Tyrrell, L Gao, D Xu, J Quan, D Gill, L Rai, Y Ding, G Plant, Y Chen, JZ Xue, AI Handa, M Greenall, K Walsh, SA Xue. Cancer Res 2014 Sept; 74(20): 1-12
  • Mesenchymal stem cells differentially mediate regulatory T cells and conventional effector T cells to protect fully allogeneic islet grafts in mice (Original Research Article) (Impact Factor 6.671 @ 2014 Thomson Reuters, Journal Citation Reports). DM Xu, XF Yu, D Zhang, MX Zhang, JF Zhou, PH Tan, YC Ding. Diabetologia 2012 Apr; 55(4):1091-102
  • Vascular endothelial growth factor receptors and cancer therapeutic targeting: where do we go from here? (Review Article) (Impact Factor 2.414 @ 2014 Thomson Reuters, Journal Citation Reports). D Bruce, PH Tan (Senior Authorship). Cell Communication & Adhesion 2011 Oct; 18(5): 85-103
  • Controlling the cost of breast cancer (Review Article) (Impact Factor 1.564 @ 2014 Thomson Reuters, Journal Citation Reports). D Gill, D Bruce, PH Tan (Senior Authorship). Eur J Cancer Care (Engl) 2011 Nov; 20(6): 703-7
  • Blocking the interaction of vascular endothelial growth factor receptors with their ligands and their effector signaling as a novel therapeutic target for cancer: time for a new look? (Review Article)
  • D Bruce, PH Tan (Senior Authorship) (Impact Factor 5.528 @ 2014 Thomson Reuters, Journal Citation Reports). Expert Opinion on Investigational Drugs 2011 Oct; 20(10): 1413-34
  • Induction of pathogenic cytotoxic T lymphocyte tolerance by dendritic cells: a novel therapeutic target (Review Article) (Impact Factor 5.139 @ 2014 Thomson Reuters, Journal Citation Reports). D Gill, PH Tan (Senior Authorship). Expert Opinion on Therapeutic Target 2010 Aug; 14(8): 797-824
  • Manipulation of indoleamine 2, 3-dioxygenase (IDO); a novel therapeutic target for treatment of diseases (Review Article) (Impact Factor 5.139 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, AK Bharath. Expert Opinion on Therapeutic Target 2009 Aug; 13(8): 987-1012
  • Targeting gene delivery to activated vascular endothelium using anti-E/P selectin antibody linked to PAMAM dendrimers (Original Research Article) (Impact Factor 1.82 @ 2014 Thomson Reuters, Journal Citation Reports). S Theoharis, U Krueger, PH Tan, DO Haskard, M Weber, AJ George. Journal of Immunological Methods 2009 Apr 15; 343(2): 79-90
  • Manipulation of indoleamine 2, 3-dioxygenase (IDO) for clinical transplantation; promises and challenges (Review Article) (Impact Factor 3.743 @ 2014 Thomson Reuters, Journal Citation Reports). J Quan*, PH Tan* (*Joint First), A MacDonald, PJ Friend. Expert Opinion on Biological Therapy 2008 Nov; 8(11): 1705-19
  • Interaction of current cancer treatments and the immune system: implications for breast cancer therapeutics (Review Article) (Impact Factor 3.543 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, AS Lota. Expert Opinion on Pharmacotherapy 2008 Oct; 9(15): 2639-60
  • More trouble ahead; is gene therapy coming of age? (Review Article) (Impact Factor 3.743 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, SE Janes, AI Handa, PJ Friend. Expert Opinion on Biological Therapy 2008 May; 8(5): 1-7
  • Modulation of the immune response by targeting endothelial cells (Review Article) (Impact Factor 2.416 @ 2014 Thomson Reuters, Journal Citation Reports). M Manunta, PH Tan, AJ George. Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents 2007 May; 6(2): 171-181
  • Gene delivery to vascular endothelium using chemical vectors; implications for cardiovascular gene therapy (Review Article) (Impact Factor 3.743 @ 2014 Thomson Reuters, Journal Citation Reports). S Theoharis, M Manunta, PH Tan (Senior Authorship) (Impact Factor 3.743 @ 2014 Thomson Reuters, Journal Citation Reports). Expert Opinion on Biological Therapy 2007 May; 7(5): 627-43
  • Changing viral tropism using immunoliposomes alters the stability of gene expression: implications for viral vector design (Original Research Article) (Impact Factor 1.554 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan*, SA Xue* (*Joint first), B Wei, A Holler, RH Voss, AJ George. Molecular Medicine 2007 Mar-Apr; 13(3-4): 216-26
  • Knockdown of mouse VCAM-1 by vector-based siRNA (Original Research Article) (Impact Factor 1.457 @ 2014 Thomson Reuters, Journal Citation Reports). AK Alam, O Florey, M Weber, RG Pillai, C Chan, PH Tan, RI Lechler, MO McClure, DO Haskard, AJ George. Transplant Immunology 2006 Nov; 16(3-4): 185-93
  • Aspirin-treated human dendritic cells upregulate ILT-3 and induce hypo-responsiveness and regulatory activity in responder T cells (Original Research Article) (Impact Factor 5.683 @ 2014 Thomson Reuters, Journal Citation Reports). M Buckland, CB Jago, H Fazekasova, K Scott, PH Tan, AJ George, R Lechler, G Lombardi. American Journal of Transplantation 2006 Sep; 6(9): 2046-59. Gene therapy for clinical transplantation; where do we stand in 2006? (Review Article) (Impact Factor 3.626 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, AJ George, AI Handa. Discovery Medicine 2006 Aug; 6(34): 153-56. Gene therapy for transplantation with viral vectors- how much of the promise has been realized? (Review Article) (Impact Factor 3.743 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, PL Tan, AJ George, CLH Chan. Expert Opinion on Biological Therapy 2006 Aug; 6(8): 759-72
  • Gene delivery by dendrimers operates via different pathways in different cells, but is enhanced by the presence of caveolin (Original Research Article) (Impact Factor 1.82 @ 2014 Thomson Reuters, Journal Citation Reports). M Manunta, B Nichols, PH Tan, P Sagoo, JE Harper, AJ George. Journal of Immunological Methods 2006 Jul; 314(1-2): 134-46
  • Strategies to improve non-viral vectors- potential applications in clinical transplantation (Review Article) (Impact Factor 3.743 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, CLH Chan, AJ George. Expert Opinion on Biological Therapy 2006 Jun; 6(6): 619-30
  • Expression of indoleamine 2, 3-dioxygenase (IDO) on endothelial cells: implications for control of alloresponses (Original Research Article) (Impact Factor 5.683 @ 2014 Thomson Reuters, Journal Citation Reports). SC Beutelspacher*, PH Tan*(*Joint First), MO McClure, DF Larkin, RI Lechler, AJ George. American Journal of Transplantation 2006 Jun; 6(6): 1320-30
  • Fat necrosis of the breast- a review (Review Article) (Impact Factor 1.411 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, LM Lai, EV Carrington, AS Opaluwa, KH Ravikumar, N Chetty, V Kaplan, CJ Kelley, ED Babu. Breast 2006 Jun; 15(3): 313-8
  • Function of indoleamine 2, 3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression (Original Research Article) (Impact Factor 4.034 @ 2014 Thomson Reuters, Journal Citation Reports). SC Beutelspacher, R Pillai, MP Watson, PH Tan, J Tsang, MO McClure, AJ George, DF Larkin. European Journal of Immunology 2006 Mar; 36(3): 690-700
  • Effect of vectors on human endothelial cell signal transduction: implications for cardiovascular gene therapy (Original research article) (Impact Factor 6.199 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, SA Xue, M Manunta, SC Beutelspacher, H Fazekasova, AK Alam, MO McClure, AJ George. Arteriosclerosis, Thrombosis, and Vascular Biology 2006 Mar; 26(3): 462-7
  • Delivery of oligodeoxynucleotides into human saphenous veins: the adjunct effect of ultrasound and microbubbles (Original Research Article) (Impact Factor 2.214 @ 2014 Thomson Reuters, Journal Citation Reports). T Kodama, PH Tan, I Offiah, T Partridge, T Cook, AJ George, MJ Blomley. Ultrasound in Medicine and Biology 2005 Dec; 31(12): 1683-1691
  • The evolving role of gene-based treatment in surgery (Review Article) (Impact Factor 5.542 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, CLH Chan, C Chan, AJ George . British Journal of Surgery 2005 Dec; 92(12): 1466-1480
  • Comparison of several viral vectors for gene therapy of corneal endothelial cells (Original Research Article) (Impact Factor 0.387 @ 2014 Thomson Reuters, Journal Citation Reports). SC Beutelspacher, N Serbecic, PH Tan, MO McClure. Ophthalmologe 2005 Dec; 102(12): 1168-74
  • Creation of tolerogenic human dendritic cells via intracellular CTLA4- a novel strategy with potential in clinical immunosuppression (Plenary Article - Original Research Article) (Impact Factor 10.452 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, JB Yates, SA Xue, C Chan, WJ Jordan, JE Harper, MP Watson, R Dong, MA Ritter, RI Lechler, G Lombardi, AJ George. Blood 2005 Nov; 106(9): 2936-2943
  • Tolerant T cells display impaired trafficking (Original Research Article). V Mirenda, O Millington, RI Lechler, D Scott, MP Hernandez-Fuentes, J Read, PH Tan, AJ George, P Garside, FM Marelli-Berg. European Journal of Immunology 2005 July, 33(7), 2146–2156
  • Inhibition of NF[kappa]B and oxidative pathways in human dendritic cells by anti-oxidative vitamins generates regulatory T cells (Original Research Article) (Impact Factor 4.922 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, P Sagoo, C Chan, JB Yates, J Campbell, SC Beutelspacher, BM Foxwell, G Lombardi, AJ George,. Journal of Immunology 2005 Jun; 174(12): 7633-44
  • Comparison of HIV-1 and EIAV-based lentiviral vectors in corneal transduction (Original Research Article) (Impact Factor 2.71 @ 2014 Thomson Reuters, Journal Citation Reports). SC Beutelspacher, N Ardjomand, PH Tan, GS Patton, DF Larkin, AJ George, MO McClure. Experimental Eye Research 2005 Jun; 80(6): 787-94
  • Modulation of human dendritic cell function following transduction with viral vectors: implications for gene therapy (Original Research Article) (Impact Factor 10.452 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, SC Beutelspacher, SA Xue, YH Wang, P Mitchell, JC McAlister, HJ Stauss, MA Ritter, DF Larkin, MO McClure, G Lombardi, AJ George. Blood 2005 May; 105(10): 3824-32
  • An efficient, non-viral alternative to viral vectors for transfection of human dendritic cells: a potential tool for clinical vaccination (Original Research Article) (Impact Factor 6.227 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, SC Beutelspacher, YH Wang, MO McClure, MA Ritter, G Lombardi, AJ George. Molecular Therapy 2005 May; 11(5): 790-80
  • Gene delivery by dendrimers operates via a cholesterol dependent pathway (Original Research Article) (Impact Factor 9.112 @ 2014 Thomson Reuters, Journal Citation Reports). M Manunta, PH Tan, P Sagoo, K Kashefi, AJ George. Nucleic Acids Research 2004 May; 32(9): 2730-9
  • Low dose of ethanol modulate toxic effect of iron-overloading in the liver (Original Research Article) (Impact Factor 0.83 @ 2014 Thomson Reuters, Journal Citation Reports). SC Beutelspacher, N Serbecic, PH Tan, M Mehrabi, P Nielson, Y Yamane. Journal of Nutritional Science and Vitaminology 2004 Apr; 50(2): 78-86
  • Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells (Original Research Article) (Impact Factor 3.944 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, C Chan, SA Xue, R Dong, B Anathesayanan, M Manunta, C Kerouedan, NJ Cheshire, JH Wolfe, DO Haskard, KM Taylor, AJ George. Atherosclerosis 2004 Apr; 173(2): 171-83  
  • Modulation of co-stimulation by CD28 and CD154 alters the kinetics and cellular characteristics of corneal allograft rejection (Original Research Article) (Impact Factor 2.489 @ 2014 Thomson Reuters, Journal Citation Reports). N Ardjomand, JC McAlister, NJ Rogers, PH Tan, AJ George, DF Larkin. Investigative Ophthalmology Visual Science 2003 Sep; 44(9): 3899-905
  • Antibody directed gene delivery to endothelium (Original Research Article) (Impact Factor 2.472 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, M Manunta, N Ardjomand, SA Xue, DFP Larkin, DO Haskard, KM Taylor, AJ George. Journal of Gene Medicine 2003 Apr; 5(4): 311-23
  • Transferrin receptor-mediated gene transfer to corneal endothelium (Original Research Article) (Impact Factor 3.828 @ 2014 Thomson Reuters, Journal Citation Reports). PH Tan, WJ King, D Chen, HM Awad, M Mackett, RI Lechler, DF Larkin, AJ George. Transplantation 2001 Feb; 71(4): 552-60
  • Gene delivery to the corneal endothelium (Review Article) (Impact Factor 12.996 @ 2014 Thomson Reuters, Journal Citation Reports). AJ George, CV Arancibia-Corcarno, HM Awad, RM Cromer, Z Fehevari, WJ King, M Hassan, T Huddle, C Lebosse, F Mirza, HB Oral, SA Rayner, PH Tan, E Tay, DF Larkin. American Journal of Respiratory and Critical Care Medicine 2000 Oct; 162(4 Pt 2): S194-200