Professor Clive Handler

Job title

Consultant in pulmonary hypertension



GMC Number


Contact details

Email address:

PA/secretary phone number: 020 7794 0500 ext 35893

Fax: 020 7317 7747

Related services

Pulmonary hypertension


Professor Handler is a consultant cardiologist working in the National Pulmonary Hypertension (PH) Unit and honorary clinical professor, division of medicine, UCL. He graduated from Guy’s Hospital Medical School, trained in cardiology at Guy’s, UCH and the Middlesex Hospitals and was consultant cardiologist at Northwick Park and St Mary’s Hospitals and honorary senior lecturer in medicine at Imperial College before being appointed to the Royal Free Hospital. He is a member of the UCL FLARRE research collaborative with interests in improving survival in PAH, clinical trials, new treatments for pulmonary hypertension, and teaching and education for doctors and lay people.  He is the author or editor of 13 books on cardiology, translational medicine, vascular biology and for patient education.


  • Sithamparanathan S, Nair A, Thirugnanasothy LCoghlan JG, Condliffe R, Dimopoulos K, Elliot CA, Fisher AJ, Gaine S, Gibbs JS, Gatzoulis MA,  Handler CE, Howard LS, Johnson M, Kiely DG, Lordan JL, Peacock AJ, Pepke-Zaba J, Schreiber BE, Sheares KK, Wort SJ, Corris PA; National Pulmonary Hypertension Service Research Collaboration of the United Kingdom and Ireland. Survival in portopulmonary hypertension: Outcomes of the United Kingdom National Pulmonary Arterial Hypertension Registry.  J Heart Lung Transplant. 2016 Dec 31. pii: S1053-2498(16)30493-4. doi: 10.1016/j.healun.2016.12.014. [Epub ahead of print]
  • Guy’s Hospital – 250 years”.  Edited by Clive E Handler, published by Guy’s Hospital Gazette, 1975
  • Diagnosis and management of cardiac arrhythmias in primary care”.  Clive E Handler. 2002 Published by Cardionetics Ltd
  • Cardiology in Primary Care”. Clive Handler. 2004, Radcliffe Publishing 
  • Classic Papers in Coronary Angioplasty”.  Ed Clive E Handler, Michael W. Cleman, 2006, Springer, 
  • Living with Coronary Disease” By Clive Handler and Gerry Coghlan, 2007.  Springer
  • Prevention of Cardiovascular Disease in Primary Care”, 2nd Edition, Clive Handler and Gerry Coghlan, Radcliffe Medical Publishing, 2008
  • Management of Cardiac Problems in Primary Care”, 2nd Edition, Clive Handler and Gerry Coghlan, Radcliffe Medical Publishing, 2008
  • Vascular Complications of Human Disease: Mechanisms and Consequences, Edited by David Abraham, Gerry Coghlan, Mick Dashwood and Clive Handler, Springer
  • Advances in Vascular Medicine. Edited by: Abraham D, Handler C, Dashwood M, Coghlan G. Springer Verlag; 2010.
  • Pulmonary Arterial Hypertension: The Facts. Clive Handler and Gerry Coghlan, OUP 2010.
  • Handler C, Handler C, Gill D. English and Reflective Writing Skills in Medicine. UK: Radcliffe Publishing; 2011.
  • Abraham D, Handler C, Dashwood M, Coghlan G (Eds) Translational Vascular Medicine. Springer; 2012.
  • Handler C, Coghlan G. Pulmonary Hypertension (Oxford Specialist Handbook). Oxford: OUP; 2012. 
  • Williams MH, Das C, Handler CE, Akram MR, Davar J, Denton CP, Smith CJ, Black CM, Coghlan JG.  Systemic sclerosis associated pulmonary hypertension: Improved survival in the current era.  Heart 2005: epub doi 10.1136/hrt 2005.069684.
  • Akram MR, Handler CE, Williams M, Carulli MT, Andron M, Black CM, Denton CP, Coghlan JG.  Angiographically proven coronary artery disease in scleroderma.  Rheumatology Advance Access published online, April 10, 2006.  doi:10.1093/rheumatology/kell20
  • Williams MH, Handler CE, Akram R, Smith CJ, Das C, Smee J, Nair D, Denton CP, Black CM, Coghlan JG.  Role of N-terminal brain natriuretic peptide (N-TproBNP) in scleroderma-associated pulmonary arterial hypertension.  Eur Heart J 2006; 27: 1485-1494
  • Carulli MT, Handler C, Coghlan JG, Black CM, Denton CP. Can CCL2 serum levels be used in risk stratification or to monitor treatment response in systemic sclerosis? Ann Rheum Dis. 2008 Jan; 67(1):105-9. Epub 2007 Jun 29
  • Valerio CJ, Handler CE, Kabunga P, Smith CJ, Denton CP, Coghlan JG. Clinical experience with bosentan and sitaxentan in connective tissue disease-associated pulmonary arterial hypertension. Rheumatology (Oxford) 2010;49(11):2147-53
  • Dobarro D, Schreiber BE, Warrell C, Handler C, Coghlan G, Denton C. Clinical Effectiveness of PAH Specific Therapies in Sarcoidosis-Related Pulmonary Hypertension. Rheumatology (Oxford) 2012;51:72
  • Schreiber BE, Dobarro D, Warrell CE, Handler C, Denton CP, Coghlan G. Big Is Beautiful: Body Size and Survival in Connective Tissue Disease Associated Pulmonary Arterial Hypertension. Rheumatology (Oxford) 2012;51:82-3
  • Schreiber BE, Valerio CJ, Keir GJ, Handler C, Wells AU, Denton CP, Coghlan JG. Improving the Detection of Pulmonary Hypertension in Systemic Sclerosis Using Pulmonary Function Tests. Arthritis Rheum 2011;63(11):3531-9
  • Dobarro D, Schreiber BE, Handler C, Beynon H, Denton CP, Coghlan JG. Clinical Characteristics, Haemodynamics and Treatment of Pulmonary Hypertension in Sarcoidosis in a Single Centre, and Meta-Analysis of the Published Data. Am J Cardiol 2013;111(2):278-85
  • Valerio CJ, Schreiber BE, Handler CE, Denton CP, Coghlan JG. Borderline mean pulmonary artery pressure in patients with systemic sclerosis: transpulmonary gradient predicts risk of developing pulmonary hypertension. Arthritis Rheum 2013; 65: 1074-84
  • Schwaiger JP, Loder CD, Dobarro D, Kaier T, Reddecliffe S, Schreiber BE, Handler C, Denton CP, Coghlan JG. Optical coherence tomography evaluation of pulmonary arterial vasculopathy in Systemic Sclerosis.  Sci Rep.  2017 Feb 24;7:43304. doi: 10.1038/srep43304.
  • Sobanski V, Giovannell J, Lynch Bm, Schreiber BE, Nihtyanova SI, Harvey J, Handler CE, Denton CP, Coghlan JG. Characteristics and Survival of Anti-U1 RNP Antibody-Positive Patients With Connective Tissue Disease-Associated Pulmonary Arterial Hypertension. Arthritis Rheumatol. 2016 Feb;68(2):484-93. doi: 10.1002/art.39432.
  • Schwaiger JP, Knight DS, Kaier T, Gallimore A, Denton CP, Schreiber BE, Handler C, Coghlan JG. Two-dimensional knowledge-based volumetric reconstruction of the right ventricle documents short-term improvement in pulmonary hypertension.  Echocardiography. 2017 Jun;34(6):817-824. doi: 10.1111/echo.13541. Epub 2017 Jun 13.