This leaflet provides more information about infliximab subcutaneous injections and what you might need to be aware of when switching.

If you have any further questions or concerns, please discuss at your next clinic appointment if it is before you are due to switch, otherwise you can contact the IBD advice line; 0207 830 2283 or email: rf.ibdnurses@nhs.net

Introduction

There are now two types (also known as ‘formulations’) of infliximab available for treatment of your inflammatory bowel disease (IBD). In addition to the intravenous infusion, which is given to you at the day infusion unit, there is an injectable version (‘subcutaneous’ or ‘under the skin’) which you can self-administer at home, every two weeks.

Will the injections work as well as the intravenous infusions?

The European Medicines Agency (EMA) has approved the safety of the injections. The company has demonstrated in large clinical trials that the two formulations are equally safe and effective. The IBD team will also monitor you during the switch and you will be reviewed in clinic at your next scheduled appointment.

Where will I have the injections?

You will need to administer the injection yourself at home. A nurse will teach you how to inject the medication safely and correctly yourself. Your injections will be delivered directly to your home.

When will the switch happen?

You will switch to the injection at the next dose of your scheduled intravenous infusion. The injections will be delivered to your home. You will no longer need to attend the hospital for your infusions.

What monitoring will I need to have?

You will continue to be monitored as normal. You must attend the hospital to have your monitoring bloods checked every three months. If you do not have your regular blood monitoring tests carried out it may mean we have to hold the delivery of your treatment until they have been checked. We will continue to monitor the levels of infliximab drug and antibodies in your blood. You will be advised when these are required. You need to ensure you attend these blood tests within one to two days before you inject your next dose.

How will I receive injections?

We will arrange for a homecare company to deliver this medication directly to your home monthly. A homecare nurse will teach you how to inject the medication yourself. The medication delivery company is HealthNet Homecare. They contact you via telephone to arrange the deliveries and initial nurse visit.

Please keep track of when your next injection is due, to avoid missing or delaying your treatment. If you have any problems with your deliveries, please contact HealthNet Homecare directly on 0800 083 3060. The homecare that delivers your medication might change due to a change in brand however you will be notified if that is the case.  

Who do I contact if I am running out of my medication?

If you are running out of medication and you haven’t heard from HealthNet Homecare please contact them directly on 0800 083 3060.

Will I be shown how to use the subcutaneous injections?

A nurse will visit your home to show you how to use the pre-filled pen. They will be able to visit two or three times if needed, until you feel comfortable with injecting yourself. You can also ask them to train a friend or family member if you are unable to inject yourself.

How often will I need to inject?

You will need to inject yourself once every two weeks.