Biography

Sorena Kiani studied medicine at University College London in the MBPhD programme, as part of which he gained a PhD in immunology.

He specialised in clinical immunology at King’s College Hospital and worked as a consultant immunologist at Royal Surrey and Barts Health before moving to Royal Free Hospital.

GMC number

4726830

  • A National Survey of Hereditary Angioedema and Acquired C1 Inhibitor Deficiency in the United Kingdom. J Allergy Clin Immunol Pract. 2023 Aug;11(8):2476-2483. doi: 10.1016/j.jaip.2023.04.035. Epub 2023 May 3. PMID: 37146882. Yong, Patrick FK, Tanya Coulter, Tariq El-Shanawany, Tomaz Garcez, Scott Hackett, Rashmi Jain, Sorena Kiani-Alikhan et al.
  • An investigational oral plasma kallikrein inhibitor for on-demand treatment of hereditary angioedema: a two-part, randomised, double-blind, placebo-controlled, crossover phase 2 trial. Lancet. 2023 Feb 11;401(10375):458-469. doi: 10.1016/S0140-6736(22)02406-0. PMID: 36774155. Aygören-Pürsün E, Zanichelli A, Cohn DM, Cancian M, Hakl R, Kinaciyan T, Magerl M, Martinez-Saguer I, Stobiecki M, Farkas H, Kiani-Alikhan S.
  • Berotralstat for the prophylaxis of hereditary angioedema-Real-world evidence data from the United Kingdom. Allergy. 2023 May;78(5):1380-1383. doi: 10.1111/all.15641. Epub 2023 Jan 24. PMID: 36609839. Ahuja M, Dorr A, Bode E, Boulton APR, Buckland M, Chee S, Dalley C, Denman S, Ekbote A, Elkhalifa S, El-Shanawany T, Eren E, Herwadkar A, Garcez T, Ghanta H, Grammatikos A, Grigoriadou S, Jain R, Lorenzo L, Manson A, Moon E, Murng S, Murphy A, Mutlu L, Peters N, Sooriyakumar K, Stroud C, Townsend K, Yellon RL, Yong P, Kiani-Alikhan S.
  • Gastrointestinal symptoms and nutritional issues in patients with hypermobility disorders: assessment, diagnosis and management. Frontline Gastroenterol. 2022 Jun 8;14(1):68-77. doi: 10.1136/flgastro-2022-102088. PMID: 36561778; PMCID: PMC9763642. Lam C, Amarasinghe G, Zarate-Lopez N, Fikree A, Byrne P, Kiani-Alikhan S, Gabe S, Paine P.
  • Lanadelumab for the prevention of hereditary angioedema attacks: A real-world UK audit. Allergy. 2023 May;78(5):1369-1371. doi: 10.1111/all.15620. Epub 2022 Dec 21. PMID: 36510404. Dorr AD, Chopra C, Coulter TI, Dempster J, Dziadzio M, El-Shanawany T, Garcez T, Gompels M, Herriot R, Jain R, Levi M, Lorenzo L, Makki I, Mapazire E, Murng SHK, Noorani S, Savic S, Steele CL, Symons C, Tarzi M, Yong PFK, Kiani-Alikhan S.
  • The international WAO/EAACI guideline for the management of hereditary angioedema - The 2021 revision and update. World Allergy Organ J. 2022 Apr 7;15(3):100627. doi: 10.1016/j.waojou.2022.100627. PMID: 35497649; PMCID: PMC9023902. Maurer M, ………., Kiani-Alikhan S, Lei WT, Lockey RF, Longhurst H, Lumry W, MacGinnitie A, Malbran A, Martinez Saguer I, Matta Campos JJ, Nast A, Nguyen D, Nieto-Martinez SA, Pawankar R, Peter J, Porebski G, Prior N, Reshef A, Riedl M, Ritchie B, Sheikh FR, Smith WB, Spaeth PJ, Stobiecki M, Toubi E, Varga LA, Weller K, Zanichelli A, Zhi Y, Zuraw B, Craig T.
  • Attenuated androgen discontinuation in patients with hereditary angioedema: a commented case series. Allergy Asthma Clin Immunol. 2022 Jan 13;18(1):4. doi: 10.1186/s13223-021-00644-0. PMID: 35027083; PMCID: PMC8759255. Maurer M, Magerl M, Aygören-Pürsün E, Bork K, Farkas H, Longhurst H, Kiani-Alikhan S, Bouillet L, Boccon-Gibod I, Cancian M, Zanichelli A, Launay D.
  • The international WAO/EAACI guideline for the management of hereditary angioedema-The 2021 revision and update. Allergy. 2022 Jul;77(7):1961-1990. doi: 10.1111/all.15214. Epub 2022 Feb 3. PMID: 35006617. Maurer, M., Magerl, M., Betschel, S., Aberer, W., Ansotegui, I.J., Aygören-Pürsün, E., Banerji, A., Bara, N.A., Boccon-Gibod, I., Bork, K. and Bouillet, L., Kiani-Alikhan S, ……………, Zuraw B, Craig T.
  • Case report: Hereditary angioedema in pregnancy. Obstet Med. 2021 Sep;14(3):177-180. doi: 10.1177/1753495X20958225. Epub 2020 Oct 7. PMID: 34646347; PMCID: PMC8504306. Jakes AD, Thorne I, Guly J, Kiani-Alikhan S, Banerjee A.
  • Measurement of C1-Inhibitor function alone is sufficient for diagnosis of hereditary angioedema. J Clin Pathol. 2022 Nov;75(11):787-788. doi: 10.1136/jclinpath-2021-207538. Epub 2021 Oct 7. PMID: 34620609. Kiani-Alikhan S, Walker E, Hickey A, Grigoriadou S, Buckland M, Scott C.
  • HELP OLE Investigators. Long-term prevention of hereditary angioedema attacks with lanadelumab: The HELP OLE Study. Allergy. 2022 Mar;77(3):979-990. doi: 10.1111/all.15011. Epub 2021 Aug 13. PMID: 34287942; PMCID: PMC9292251. Banerji A, Bernstein JA, Johnston DT, Lumry WR, Magerl M, Maurer M, Martinez-Saguer I, Zanichelli A, Hao J, Inhaber N, Yu M, Riedl MA
  • Long-term safety and effectiveness of berotralstat for hereditary angioedema: The open-label APeX-S study. Clin Transl Allergy. 2021 Jun;11(4):e12035. doi: 10.1002/clt2.12035. PMID: 34161665; PMCID: PMC8221587. Farkas H, Stobiecki M, Peter J, Kinaciyan T, Maurer M, Aygören-Pürsün E, Kiani-Alikhan S, Wu A, Reshef A, Bygum A, Fain O, Hagin D, Huissoon A, Jeseňák M, Lindsay K, Panovska VG, Steiner UC, Zubrinich C, Best JM, Cornpropst M, Dix D, Dobo SM, Iocca HA, Desai B, Murray SC, Nagy E, Sheridan WP.
  • Randomized Trial of the Efficacy and Safety of Berotralstat (BCX7353) as an Oral Prophylactic Therapy for Hereditary Angioedema: Results of APeX-2 Through 48 Weeks (Part 2). J Allergy Clin Immunol Pract. 2021 Jun;9(6):2305-2314.e4. doi: 10.1016/j.jaip.2021.03.057. Epub 2021 Apr 15. PMID: 33866032. Wedner HJ, Aygören-Pürsün E, Bernstein J, Craig T, Gower R, Jacobs JS, Johnston DT, Lumry WR, Zuraw BL, Best JM, Iocca HA, Murray SC, Desai B, Nagy E, Sheridan WP, Kiani-Alikhan S.
  • ‘Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report’ Buckland MS, ……, Kiani-Alikhan S, ……, Thaventhiran JED  Nature Commun. 2020 Dec 14;11(1):6385. doi: 10.1038/s41467-020-19761-2. PMID: 33318491; PMCID: PMC7736571.
  • ‘Successful treatment of a patient with chronic systemic capillary leak syndrome, neutropenia and thymoma.’  Rohit R. Ghurye, Asim Khan, Timothy Yung, Sorena Kiani-Alikhan, Debasish Pyne, *, and Sofia Grigoriadou, * J Clin Immunol . 2020 Jan;40(1):240-244. doi: 10.1007/s10875-019-00722-4. Epub 2019 Dec 4
  •  ‘Immunoglobulin abnormalities are frequent in patients with lupus nephritis.’ Cuadrado MJ, Calatayud I, Urquizu-Padilla M, Wijetilleka S, Kiani-Alikhan S, Karim MY.BMC Rheumatol. 2019 Aug 21;3:30. doi: 10.1186/s41927-019-0079-2. eCollection 2019.PMID: 31453435
  • ‘Immunoglobulin replacement for secondary immunodeficiency after B-cell targeted therapies in autoimmune rheumatic disease: Systematic literature review.’ Wijetilleka S, Mukhtyar C, Jayne D, Ala A, Bright P, Chinoy H, Harper L, Kazmi M, Kiani-Alikhan S, Li C, Misbah S, Oni L, Price-Kuehne F, Salama A, Workman S, Wrench D, Karim MY. Autoimmun Rev. 2019 May;18(5):535-541. doi: 10.1016/j.autrev.2019.03.010. Epub 2019 Mar 4. PMID: 30844552  
  • ‘Quantification of human C1 esterase inhibitor protein using an automated turbidimetric immunoassay’ Tange CE, Kaur A, Verma N, Hickey A, Grigoriadou 2, Scott C, Kiani S, Steven R, Ponsford M, El-Shanawany T, Jolles S, Harding S, Parker AR. J Clin Lab Anal. 2019 Jan;33(1):e22627. doi: 10.1002/jcla.22627. Epub 2018 Jul 29.
  •  ‘Recommendations for the management of secondary hypogammaglobulinaemia due to B-cell targeted therapies in autoimmune rheumatic diseases’ Wijetilleka S, Mukhtyar C, Jayne DR, Ala A, Bright PD, Chinoy H, Harper L, Kazmi MA, Kiani-Alikhan S, Li CK, Misbah SA, Oni L, Price-Kuehne FE, Salama AD, Workman S, Wrench D, Karim MY. Rheumatology (Oxford). 2018 Dec 26. doi: 10.1093.
  • ‘Quantification of human C1 esterase inhibitor protein using an automated turbidimetric immunoassay’ Clare Elizabeth Tange, Amrit Kaur, Nisha Verma, Alaco Hickey, Chris Scott, Sorena Kiani-Alikhan, Stephen Harding  and Antony Richard Parker, Stephen JollesAccepted for publication; DOI:10.1002/jcla.22627 Journal of Clinical Laboratory Analysis
  • ‘Masurement and interpretation of Salmonella typhi Vi IgG antibodies for the assessment of adaptive immunity’Parker AR, Bradley C, Harding S, Sánchez-Ramón S, Jolles S, Kiani-Alikhan S. J Immunol Methods. 2018 May 22. pii: S0022-1759(17)30454-4. doi: 10.1016/j.jim.2018.05.013.
  • ‘Whole Genome Sequencing identifies NFKB1 haploinsufficiency as the commonest monogenic cause of Common Variable Immunodeficiency’
  • Paul Tuijnenburg, Hana Lango Allen, Siobhan O.Burns, Machiel H Jansen Emily Staples, Keren J.Carss, Daniele Biasci5, Helen Baxendale5, Moira Thomas, Anita Chandra5, Sorena Kiani-Alikhan, Hilary J.Longhurst, Eric Oksenhendler, Ilenia Simeoni, Godelieve J. de Bree, Anton T.J. Tool, Ester M.M. van Leeuwen, Eduard H.T.M. Ebberink, NIHR BioResource Rare Diseases Consortium, Adrian J.Thrasher, Ken G. C.Smith, James E. Thaventhiran, Taco W. Kuijpers. J Allergy Clin Immunol. 2018 Mar 2. pii: S0091-6749(18)30286-0. doi: 10.1016/j.jaci.2018.01.039.
  • ‘Low IgA & IgM correlate with a higher prevalence of bronchiectasis in primary antibody deficiency’
    John Hodkinson, Cathy Bangs, Andrea Wartenberg-Demand, Artur Bauhofer, Patrick Langohr, Matthew Buckland, David Guzman, Patrick Yong, Sorena Kiani-Alikhan. J Clin Immunol. 2017 May;37(4):329-331; doi: 10.1007/s10875-017-0381-y. Epub 2017 Mar 14.
  • ‘Combined low IgM and IgA at diagnosis correlates with higher prevalence of bronchiectasis in PID - UKPIN registry analysis ’
  • John Hodkinson, Cathy Bangs, Matthew Buckland, David Guzman, Patrick Yong, Sorena Kiani-Alikhan .Poster presentation UKPIN biennial meeting Belfast 2015
  • ‘Hypogammaglobulinaemia after rituximab treatment:incidence and outcomes’
    Makatsori M, Kiani-Alikhan S, Manson AL, Verma N, Leandro M, Gurugama NP, Longhurst HJ, Grigoriadou S, Buckland M, Kanfer E, Hanson S, Ibrahim MA, Grimbacher B, Chee R, Seneviratne SL. QJM. 2014 Oct;107(10):821-8. doi: 10.1093/qjmed/hcu094. Epub 2014 Apr 28.PMID: 24778295
  • ‘Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients’G K. Wong, S Goldacker, C Winterhalter, B Grimbacher, H Chapel, M Lucas, D Alecsandru, D McEwen, I Quinti, H Martini, C, R E Schmidt, D Ernst, T Espanol, A Vidaller, J Carbone, E Fernandez-Cruz, V Lougaris, A Plebani, N Kutukculer, L I Gonzalez-Granado, R Contreras, S Kiani-Alikhan, M A. A. Ibrahim, J Litzman, A Jones, H. B Gaspar, L Hammarstrom, U Baumann, K Warnatz, A P. Huissoon: on behalf of the Clinical Working Party of the European Society for Immunodeficiencies (ESID). Clinical and Experimental Immunology; 2013 Apr;172(1):63-72. doi: 10.1111/cei.12039. Erratum in: Clin Exp Immunol. 2013 Jul;173(1):161. Milito, C [added].
    PMID: 23480186
  • ‘Immunoglobulin replacement therapy: Is there a role for IgA and IgM?’
    Kiani-Alikhan S, Yong PF, Grosse-Kreul D, Elston C, Ibrahim MA. J Allergy Clin Immunol. 2012 Aug;130(2):553-4. Epub 2012 Jun 2., PMID: 22664164
  • ‘Phenotypic heterogeneity in a family with a CD40 ligand intracellular domain mutation’
    Kiani-Alikhan S, Yong PF, Gilmour KC, Grosse-Kreul D, Davies EG, Ibrahim MA.
    J Clin Immunol. 2012 Feb;32(1):70-7. Epub 2011 Oct 19.
    PMID: 22009004
  • ‘Chronic fatigue syndrome, the immune system and viral infection’
    Bansal AS, Bradley AS, Bishop KN, Kiani-Alikhan S, Ford B.
    Brain Behav Immun. 2012 Jan;26(1):24-31. Epub 2011 Jul 2. Review.
    PMID: 21756995
  • ‘Successful desensitization to immunoglobulin A in a case of transfusion-related anaphylaxis’
    Kiani-Alikhan S, Yong PF, Grosse-Kreul D, Height SE, Mijovic A, Suddle AR, Ibrahim MA.
    Transfusion. 2010 Sep;50(9):1897-901.
    PMID: 20456696
  • ‘Enterovirus infection of neuronal cells post-Rituximab’
    Kiani-Alikhan S., Skoulidis F,, Barroso A., Nuovo G., Ushiro-Lumb I., Breuer J., Lister A., Mattes F.
    British journal of haematology 2009;146(3):333-5. Epub 2009 May 19.
    PMID: 19466969
  • ‘KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells’
    Henson S. M., Franzese O., Macaulay R., Libri V., Azevedo R. I., Kiani-Alikhan S., Plunkett F. J., Masters J. E., Jackson S., Griffiths S.J., Pircher H.P, Soares M.V., Akbar A.N.
    Blood 2009; 113(26): 6619 - 6628. Epub 2009 Apr 30.
    PMID: 19406987
  • ‘The use of the inhibitory receptors for modulating the immune responses’
    Henson S. M., Macaulay R., Kiani-Alikhan S., Akbar A. N.
    Current pharmaceutical design 2008;14(26):2643-50.
    PMID: 18991683
  • ‘Plasma TGFβ1 during pelvic radiotherapy for gynaecological malignancy’
    Coker R., Kiani-Alikhan S., Stewart A., Pusey C., Dale R.G., Jones B.
    Acta Oncol. 2006; 45(6):753-4
    PMID: 16938820

He has an interest in the gastrointestinal manifestation of immunodeficiency and has had extensive experience in clinical trials of hereditary angioedema and primary immune deficiency diseases.